Medical Bibliography

Barinaga, Marcia. “Missing Alzheimer’s Gene Found.” Science 269:5226 (18 August 1995): 917-918.

 

Reports on the discovery of the gene that causes Alzheimer's disease in `Volga German' families. Gene on chromosome one; Understanding the disease; Identification of Volga Germans as Alzheimer's carrying families; Studies by Gerard Schellenberg and colleagues; Usefulness of the sequenced gene.

 

Levy-Lehad, Ephrat and Wijsman, Ellen M.  “A Familial Alzheimer's Disease Locus on Chromosome I.” Science 269:5226 (18 August 1995): 970-974.

 

Demonstrates the presence of Alzheimer's disease (AD) locus on chromosome 1q31-42. Clustering of AD cases in a family; Inheritance of AD in Volga German (VG) kindreds; Absence of some genotypes in the VG pedigrees; Presence of phenocopies; Construction of haplotypes.

 

 

Levy-Lahad, Ephrat and Wasco, Wilma. “Candidate Gene for the Chromosone 1 Familial Alzheimer’s Disease Locus. Science 269:5226 (18 August 1995): 973-978.

 

Identifies a candidate gene for the chromosome one Alzheimer's disease (AD) locus (STM2). Predicted amino acid sequence of STM2; Study of nine Volga German families; Strategies in identifying AD chromosome one gene; Screening of coding region for mutations; Evaluation of nonmutation carriers.

 

Schellenberg, Gerard D. and Bird, Thomas D. “Genetic Linkage Evidence for a Familial Alzheimer’s Disease Locus on Chromosome 14. Science 258:5082 (23 October 1992): 668-672.

 

Presents a study of markers on chromosome 14 that gave highly significant positive lod scores in early-onset non-Volga German kindreds. Linkage analysis to search the genome for chromosomal regions harboring familial Alzheimer's disease genes; Evidence indicating a familial Alzheimer's disease locus on chromosome 14.